期刊文献+

HBV cccDNA的检测及其意义 被引量:3

下载PDF
导出
摘要 乙型肝炎病毒cccDNA在感染者肝内长期存在,并作为HBV复制的模板,成为根治乙型肝炎病毒感染的困难所在。因此,准确地检测肝内和/或血清HBV cccDNA的量对病情判断、疗效评估和预后均有重要的意义。本文就近年发展的检测HBV cccDNA的方法学作一介绍。
作者 陈从新
机构地区 解放军第
出处 《实用肝脏病杂志》 CAS 2007年第5期346-348,共3页 Journal of Practical Hepatology
  • 相关文献

参考文献13

  • 1WURSTHORN K, LUTGEHETMANN M, DANDRI M, et al. Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B[J]. Hepatology, 2006,44:675-684. 被引量:1
  • 2WERLE-LAPOSTOLLE B, BOWDEN S, LOCARNINI S, et al. Persistence of cccDNA during the narural history of chronic hepatitis B and decline during adefovir dipivoxil therapy[J]. Gastroenterology, 2004,126: 1750-1758. 被引量:1
  • 3LARAS A, KOSKINAS J, DIMOU E, et al. Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients [J]. Hepatology, 2006,44:694-702. 被引量:1
  • 4JUN-BIN S, ZHI C, WEI-QIN N,et al. A quantitative method to detect HBV cccDNA by chimeric primer and real-time polymerase chain reaction[J]. J Virol Methods ,2003,112:45-52. 被引量:1
  • 5STOLL-BECKER S, REPP R, GLEBE D, et al. Transcription of hepatitis B virus in peripheral blood mononuclear cells from persistently infected patients[J]. J Virol, 1997,71 : 5399-5407. 被引量:1
  • 6WONG DKH, YUEN MF, YUAN H, et al. Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients[J]. Hepatology ,2004,40:727-737. 被引量:1
  • 7MASON AL, XU L, GUO L, et al. Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen[J]. Hepatology, 1998,27:1736-1742. 被引量:1
  • 8CHOU YC,JENG KS, CHEN ML, et al. Evaluation of transcriptional efficiency of hepatitis B virus covalently closed circular DNA by reverse transcription-PCR combined with the restriction enzyme digestion method[J]. J Virol, 2005,79 ( 3 ) : 1813-1823. 被引量:1
  • 9WONG D KH, YUEN MF, POON RTP,et al. Quantification of hepatitis B virus covalently closed circular DNA in patients with hepatocellular carcinoma[J]. J Hepatol, 2006, 45:553 - 559. 被引量:1
  • 10TAKEHARA T, SUZUKI T, OHKAWA K, et al. Viral covalently closed circular DNA in a non-transgenicmouse model for chronic hepatitis B virus replication[J]. J Hepatol, 2006,44:267-274. 被引量:1

同被引文献47

引证文献3

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部