摘要
目的观察消纤方对淤热互结慢性肝病纤维化及相关指标的影响。方法选择慢性肝病纤维化患者46例,其中淤热互结型23例,观察淤热互结程度与血清Ⅳ胶原(CⅣ)、透明质酸(HA)的关系。淤热互结组患者给予消纤方治疗,分别于治疗前、治疗后3、6个月,以彩色多普勒超声检查患者肝脏门静脉直径(PD)、门静脉循环血流量(PBD)以及放射免疫法(RIA)测定血清CⅣ和HA。结果淤热互结程度积分与CⅣ、HA水平呈正相关(P<0.05)。消纤方治疗痰热互结慢性肝病纤维化不同治疗时间PD、PBD及血清纤维化指标测定结果比较,差异均有显著性意义(P<0.05)。结论淤热互结程度与CⅣ、HA呈正相关。消纤方可明显降低淤热互结慢性肝病纤维化相关指标的水平,一定程度上缓解了门脉高压。
Objective To observe the effects of Xiaoxian prescription on hepatic fibrosis and related index of chronic liver disease. Methods Among 46 patients with chronic hepatic fibrosis, there was 23 patiens with a stagnant heat and mutual tie （SHMT）. We observed the relation between SHMT degree and scrum collagen （C IV ） and hyaluronic acid （HA）. The SHMT group were given a treatment of Xiaoxian prescription. Before the treatment and after three - month and six - month treat- ment, scrum C]V and HA were determined by PBD and RIA, and diameter of hepatic portal vein by color Doppler ultrasonoscope. Results The score of SHMT degree had positive correlation with levels of C]V and HA （ P 〈0. 05）. There was significant difference in PD and PBD between the treatment results of the third month and that of the sixth month （ P 〈 0. 05）. Condusion The SHMT degree has positive recolation with C IV and HA. The Xiaoxian prescription can decrease significantly the index level of SHMT chronic hepatic fibrosis, and remit portal hypertension to a certain extent.
出处
《中国全科医学》
CAS
CSCD
2007年第20期1736-1738,共3页
Chinese General Practice
关键词
慢性肝病
消纤方
淤热互结
肝纤维化
Chronic liver disease
Xiaoxian prescription
Stagnated heat mutually ties
Liver fibrosis
