摘要
目的探讨还原型谷胱甘肽对2型糖尿病早期肾病患者尿清蛋白排泄率的影响。方法76例2型糖尿病早期肾病患者随机分为两组:治疗组38例患者口服还原型谷胱甘肽片(0.4g,3次/d);对照组38例患者口服安慰剂维生素B1(10mg,3次/d),两组患者均治疗3个月。比较两组患者治疗前后尿清蛋白排泄率(UAER)。结果治疗后两组患者UAER间差别有显著性意义(P<0.01),治疗后两组患者血压、肝肾功能、血糖、糖化血红蛋白及血脂间差别无显著性意义(P>0.05)。结论还原型谷胱甘肽能显著减少2型糖尿病早期肾病患者尿清蛋白的排泄,对2型糖尿病早期肾病具有治疗作用,且安全性好。
Objective To evaluate the efficacy of Reduced glutathione in treating incipient nephropathy in type 2 diabetic patients. Methods Seventy six cases of type 2 diabetics with microalbuminuria were randomized into two groups, with 38 cases in each. The patients in the trial group were orally given reduced glutathione （0.4 g, tid） for 3 months. Whereas, those in the control group received vitamin B1（ 10mg, tid） also for 3 months. Before and after the treatment the change of urinary albumin excretion rate （UAER） was investigated. Results After treatment there was a significant difference in UAER between the two groups （P〈0.01） ; and there were no significant differences in blood pressure, renal and liver functions, blood sugar, glycosylhemoglobin and blood lipid between the two groups （P〉0.05）. Conclusion Reduced glutathione can decrease urine albumin excretion efficiently in the type 2 diabetic patients with incipient nephropathy. It is safe and well tolerated.
出处
《中国全科医学》
CAS
CSCD
2007年第19期1606-1608,共3页
Chinese General Practice
