摘要
以对氯苯胺为原料，经缩合、环合、还原、甲氧甲酰化、氨解而得１－氨基甲酰－５－氯－２，３－二氢吲哚－２－酮，进而合成消炎药替尼达普。原料易得，反应条件温和，可实现工业化。
A modified method for synthesis of tenidap via condensation,cyclization,reduction,methoxycarboxylation and amination,starting from p chloroaniline to obtain the important intermediate 5 chloro 2,3 dihydroindol 2 one 1 carboxamide was described.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1997年第5期199-201,共3页
Chinese Journal of Pharmaceuticals
关键词
消炎药
替尼达普
合成
对氯苯胺
二氢吲哚
anti inflammatory agent,tenidap,synthesis, p chloroaniline,5 chloroindol 2 one 1 carboxamide
