摘要
目的建立一个三单元集中参数模型来模拟脑血流的自动调节功能。方法根据Bloor的实验数据拟合了一条在脑血流自动调节功能中,反映脑血流量和平均动脉压之间关系的三次曲线,然后利用这一拟合曲线来确定模型中的不定常电阻元件。结果利用这一模型,对不同压力变化情况下的脑血流量变化进行了数值模拟。通过与实验数据进行了对比,发现这一不定常三单元模型能够较为简单地模拟脑血流自动调节功能。结论经过改造的这一三单元集中参数模型可以为脑血流自动调节功能及脑血管疾病的研究提供帮助。
Objective To construct a lumped dynamic model with 3 elements to simulate the autoregulation of cerebral blood flow. Method According to the experimental data given by Byron M. Bloor in his book ＇Cerebral Hemodynamics in Man and Monkey＇, a cubic curve which represents the relationship between Cerebral Blood Flow （CBF） and Mean Artery Blood Pressure （MABP） is fitted. Utilizing this curve, the resistance, which is not constant in the model, is determined. Results By using this model, the procedures that CBF varies when ABP increases or decreases are numerically simulated. Conclusions Comparing our simulated results with the experimental data, we found this model can be used to simulate the autoregulation of cerebral blood flow, which is helpful for the research of Cerebrovascular Diseases.
出处
《医用生物力学》
EI
CAS
CSCD
2007年第3期268-272,276,共6页
Journal of Medical Biomechanics
关键词
脑血流自动调节
集中参数模型
血流动力学
Autoregulation of cerebral blood flow
Lumped dynamic model
Hemodynamics
