摘要
目的制备法莫替丁脉冲控释片。方法以脉冲控释片在人工胃液和人工肠液中的释放度为指标,采用正交设计进行处方筛选和优化。结果按优化处方成功制备法莫替丁脉冲控释片。释放度实验表明,4 h内有一个速释过程,经约8 h的时滞后,又产生一个符合H iguch i动力学模型的释药过程。结论该制剂体外释药具有脉冲释药特点,有利于提高消化性溃疡疾病的治疗效果。
Objective To prepare pulse controlled-release tablets of famotidine. Methods The screening and optimization of the formula of the tablets were carried out with an orthogonal design by using the amount of the drug released in an artificial gastric juice and intestinal juice as the index. Results Pulse controlled-release tablets of famotidine were successfully prepared according to the optimized formula. The dissolution release tests demonstrated that a fast release process took place within 4 hours and following a lag of round 8 hours, another drug release process was produced that accorded with the Higuehi dynamics model. Conclusion The preparation was shown to be provided with a distinguishing feature of pulse release of the drug in vitro which is advantageous to the improvement of its therapeutic effect in the treatment of peptic ulcer.
出处
《医药导报》
CAS
2007年第10期1196-1198,共3页
Herald of Medicine
关键词
法莫替丁
脉冲控释片
正交设计
Famotidine
Pulse controlled-release tablets
Orthogonal design
