摘要
目的考察氟比洛芬酯的合成工艺。方法将四氢荼与液溴反应,生成的溴化氢气体溶于无水乙酸,将此溶液与醋酸乙烯酯反应,生成乙酸-1-溴乙酯,氟比洛芬与乙酸-1-溴乙酯缩合,生成氟比洛芬酯。结果及结论此合成工艺原料易得、操作简便,适于氟比洛芬酯的开发与生产。
OBJECTIVE To synthesize Flurbiprofen Axetil. METHODS Tetrahydronaphthalene was treated with bromine to produce hydrogen bromide. The hydrogen bromide was dissolved in anhydrous acetic acid, and this solution was reacted with vinyl acetate to prepare 1-（acetoxy）ethyl bromide. Flurbiprofen Axetil was synthesized by esterfication of Flurbiprofen with 1-（acetoxy）ethyl bromide. RESULTS and CONCLUSION Raw materials are easily obtained. Synthesis route is simple and suitable for development and manufacture.
出处
《齐鲁药事》
2007年第9期557-558,共2页
qilu pharmaceutical affairs
关键词
氟比洛芬酯
镇痛
合成
Flurbiprofen Axetil
analgesics
synthesis
