摘要
目的探讨survivin蛋白在膀胱移行细胞癌中的表达规律及与VEGF受体Flt-1和Flk-1的关系分析。方法62例膀胱移行细胞癌中病理分级高分化16例、中分化26例、低分化20例;临床分期表浅型27例、浸润型35例。采用SABC染色法进行survivn和Flt-1、Flk-1表达的免疫组织化学检测。结果Survivin表达阳性率为69.4%(43/62),不同肿瘤病理分级、临床分期及淋巴结转移survivn表达显著不同。Survivin表达与Flk-1及Flt-1表达显著相关。结论Survivin在膀胱移行细胞癌中表达率较高,与Flk-1及Flt-1显著相关。
Objective To explore the expression of survivin in bladder transitional cell carcinomas and to analysis the relationship with VEGF recepoter Fit- 1 and Flk- 1. Methods Sixty-two specimens of patients of transitional cell careinonma of bladder were included in this experiment. Among them, 16 cases were in gradel, 26 in grade 2 and 20 in grade 3, Classified by clinical period, 27 cases were superficial type, 35 were infihmtion type. The expression of survivin, Fit-1 and Flk-1 was detected with the technology of immtmohistochemistry staining. Results The positive rate of survivin was 69.4% （43/62） .The expression of survivin was different according to the pathology grade of tumor, clinical stage and lymph node metastasis. The expression of survivin was correlated with the expression of Fit-1 and Flk-1 respectively. Conclusion The expression of survivin plays and important role in the occurrence of bladder transitional cell carcinomas. It was much correlated with the expression of Fit- 1 and Flk- 1.
出处
《四川医学》
CAS
2007年第9期973-975,共3页
Sichuan Medical Journal
