摘要
目的探讨153钐-乙二胺四甲基膦酸（^153Sm-EDTMP）治疗肺癌、乳癌及前列腺癌骨转移所致骨痛的疗效。方法静脉注射^153Sm-EDTMP,给药剂量18.5～37 MBq/kg（0.5～1.0 mCi/kg）,每隔1～3个月注射1次。结果前列腺癌、乳癌及肺癌^153Sm-EDTMP治疗骨痛的总有效率分别为96.3%、87.7%及69.7%,且乳癌和前列腺癌的疗效与肺癌相比差异有统计学意义（P〈0.05）,部分患者（54.5%）白细胞（WBC）或血小板（plt）可逆性减少。结论放射性核素治疗对以成骨反应为主的骨转移灶,止痛效果明显,方法简便,副作用小。
Objective To approach the clinical effects of ^153 sm - ethylene diamine tetramethylene phosphonate（ ^153 Sm - EDT- MP） treating bone metastases of malignant tumours including lung cancer, breast cancer, prostate cancer and so on. Methods Two hundred and thirty -one patients with bone metastases were intravenously received ^153Sm- EDTMP, 18.5 -37 MBq/kg （0. 5 - 1.0 mCi/kg ） body weight, once a month or three. Results The effective rate of bone - pain palliation of ^153Sm - EDT- MP treating bone metastases of prostate cancer, breast cancer and lung cancer were 96.3%, 87.7% and 69. 7%, respectively, there was an obvious difference between lung cancer and breast cancer, （ P 〈 0.05 ）. 54.5 % of patients had side effect of transient leukopenia or thrombocypenie. Conclusion ^153Sm - EDTMP might get a wide - using method in treating bone metastases of breast cancer and prostate cancer. It is easy to handle and has rare side effect and definite clinical effect.
出处
《中原医刊》
2007年第17期19-20,共2页
Central Plains Medical Journal
关键词
多发性骨转移癌
153钐-乙二胺四甲基膦酸
放射性核素
Disseminated bony metastases
^153 Sm - ethylene diamine tetramethylene phosphonate
Radionuclide
