摘要
背景与目的:顺铂与氟尿嘧啶是治疗晚期头颈部肿瘤疗效确切的药物,但有一定的毒性反应。本研究观察持续静脉滴注氟尿嘧啶联合顺铂治疗晚期头颈部癌的疗效及安全性。方法:22例晚期头颈部癌患者给予氟尿嘧啶750mg/(m2.d)持续静脉滴注5d(120h),顺铂25mg/(m2.d),d1~3。21d为一个周期,2个周期后评价疗效。结果:CR1例(4.5%),PR8例(36.4%),近期客观有效率为40.9%(9/22)。中位TTP7.4个月,1年生存率为72.7%。初治与复治有效率分别为75.0%(6/8),21.4%(3/14),统计学差异有显著性(χ2=6.04,P<0.05)。主要毒副反应为骨髓抑制、胃肠道反应和粘膜炎。结论:持续静脉滴注氟尿嘧啶联合顺铂治疗晚期头颈部癌具有较好的疗效,安全性好。
Background and purpose:Cisplatin and 5-fluorouracil (5-FU) have demonstrated significant activity in patients with advanced head and neck cancer despite relevant toxicity. We evaluated the efficacy and toxicity of combination chemotherapy using continuous intravenous infusion 5-FU plus cisplatin for locally advanced, recurrent, or metastatic head and neck cancer patients. Methods:twenty-two patients with locally advanced, recurrent, or metastatic head and neck cancer were treated by cisplatin 25 mg/(m2·d) day 1-3 and fluorouracil 750 mg/(m2·d) 120 hours by continuous intravenous infusion day 1 through 5 every 21 days as one cycle.Results:Of 22 assessable patients, 1 (4.5%)showed completed response and 8 partial response with an overall response rate of 40.9%(9/22). Median time to progression was 7.7 months, and 1-year survival was 72.2%. The toxicity mainly included grade 1/2 myleosuppression, reaction of stomach intestinal, mucositis. Response rate of initial treatment and retreatment were 75.0%(6/8),21.4%(3/14), respectively (χ2=6.04,P〈0.05).Conclusions:chemotherapy with 5-FU by continous intravenous infusion and cisplatin is safe and effective for patients with locally advanced, recurrent, or metastatic head and neck cancer.
出处
《中国癌症杂志》
CAS
CSCD
2007年第9期716-718,共3页
China Oncology
关键词
头颈部肿瘤
氟尿嘧啶
顺铂
晚期
化学治疗
head and neck neoplasm
fluorouracil
cisplatin
advanced
chemotherapy