摘要
目的:观察疏肝、健脾、疏肝健脾方药对肠易激综合症(IBS)模型大鼠的治疗效果,并探讨其作用机理。方法:采用新生鼠母子分离复合避水应激大鼠模型,测定用药前后大鼠腹部收缩反射痛阈值、应激诱导的排便粒数及结肠中五羟色胺与P物质的含量变化。结果:柴胡疏肝散、痛泻要方均能明显提高大鼠痛阈值,显著减少应激诱导的排便粒数,降低结肠中五羟色胺与P物质的含量,其中痛泻要方的作用优于柴胡疏肝散。结论:疏肝健脾的代表方痛泻要方对IBS模型大鼠具有显著的治疗作用,其疗效优于单纯疏肝方药柴胡疏肝散;其作用机理可能与降低结肠中5-HT、SP含量有关。
Objective：To observe the curative effects of prescription of soothing the liver, prescription of strengthening the spleen and prescription of soothing the liver and strengthening the spleen on IBS model rats, and to probe into its mechanism.Methods：Newly-borm model rats separated from mother in water avoidance stress were chosen to detect the pain threshold in contraction of rats＇ abdomen the grains of defecation induced by stress and the content of 5-H and substance P in colon.Results：Both Chaihu Shugan Powder and Tongxie Prescription could increase rats＇ pain threshold apparently ,and reduce the grains of defecation induced by stress and serotonin and substance P in the colon.And the effects of Tongxie Prescription were superior to that of Chaihu Shugan Powder Conclusions：As a representative prescrption of soothing the liver and strengthening the spleen,Tongxie Prescription had appsrent curative effects on IBS model rats.And its curative effects were better than that of Chaihu Shugan Powder.The mechanism maybe connect with redcing 5-H and SP in the colon.
出处
《河南中医》
2007年第9期23-25,共3页
Henan Traditional Chinese Medicine
基金
广东药学院科研基金项目(编号:43540060)
关键词
肠易激综合症
新生鼠母子分离
避水应激
疏肝健脾方药
大鼠
IBS
newly-bom model rats separated from mother
water avoidance stress
Prescription of Shugan Jianpi rats
