摘要
目的研究西洋参茎叶总皂苷的氧化碱解产物。方法采用反复硅胶柱色谱、Sephadex LH-20、重结晶等方法进行分离纯化,并根据理化常数和光谱数据鉴定其化学结构。结果从西洋参茎叶总皂苷氧化碱解产物中分离鉴定了4个主要水解产物,分别为:20(S)原人参二醇(1)、24(R)-ocotillol(2)、20(S)原人参三醇(3),dammar-20S,24R-epoxy-3β,12β,25-triol(4)。结论化合物4为首次从氧化碱解产物中分离得到,探讨其产生机理,可能是在高温通氧的条件下,使原人参二醇的侧链发生了环合。
Objective To study the alkaline-degradation products of total ginsenosides from leaves and stems of Panax quinquefolium L. Methods The compounds were isolated by chromatography on silica gel column and identified on the basis of physico-chemical evidences and spectral analysis. Results 4 compounds were identified as 20 （ S ） -protopanaxadiol （ 1 ）, 24 （ R ）-ocotillol （2）, 20 （ S ）-protopanaxatrial （ 3 ）, dammar-20 S, 24R-epoxy-3β, 12β, 25-trio1（4）. Conclusions Compound 4 is obtained from this alkaline-degradation prod- ucts for the first time. The mechanism of the formation of compound 4 is discussed.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2007年第9期552-555,共4页
Journal of Shenyang Pharmaceutical University
关键词
西洋参茎叶总皂苷
氧化碱解
化学成分
Panax quinquefolium L.
alkaline-degradation
chemical consitutents
