摘要
胸水是肺部多种疾病的常见并发症,其中绝大多数恶性胸水是由肺腺癌引起。常规细胞学检查主要根据细胞形态进行诊断,由于腺癌细胞与反应性间皮细胞形态极为相似,故鉴别以上两种细胞是诊断恶性胸水的最大难点。MOC-31特异的表达于肺癌患者胸水内的癌细胞,而不表达或低表达于反应性间皮细胞,通过多种手段对其进行检测,可为临床肺癌的诊断提供科学依据。
Pleural effusions are common complications that may he produced by a wide variety of lung diseases. Most of malignant pleural effusions are clue to adenocarcinoma of lung. Conventional cytologic diagnosis is based on cytomorphology, however, as cells of adenocarcinoma and reactive mesothelial proliferation are extremely similar in morphology, the distinction between these two entities may be the most vexing problem in the diagnosis of malignant pleural effusions. MOC-31 is expressed in carcinoma cells of patients with lung cancer,whereas is not in reactive mesothelial proliferation specifically, which was detected by various means. Thus, MOC-31 can provide scientific evidence for diagnosing lung cancer in clinic.
出处
《国际呼吸杂志》
2007年第18期1416-1418,共3页
International Journal of Respiration
基金
基金项目：沈阳市科技局科研项目（编号：1053125-1-52）
关键词
肿瘤标记
生物学
肺肿瘤
胸水
胸腔积液
Tumor markers
Biology
Lung neoplasms
Hydrothorax
Pleural effusion
