摘要
Toll样受体（TLRs）是一类模式识别受体，该家族成员可选择性识别保守的微生物成分（如细菌脂多糖、病毒双链RNA）而启动天然免疫并调节获得性免疫，因此，TLR在宿主的免疫识别与免疫应答调控中具有重要作用。TLR可激活一系列的信号转导通路，其中包括丝裂原激活的蛋白激酶（MAPK）家族和NF—κB通路。MAPK信号通路的激活调控了一系列的细胞活动，在细胞的增殖、分化、凋亡等过程中起着重要的作用。越来越多的研究表明，中间分子MAPKKK（MAP3K）在不同的细胞或在不同的细胞外刺激下激活不同的MAPK信号途径。
Members of the Toll-like receptor （TLR） family recognize conserved microbial structures, such as bacterial lipopolysaccharide and viral double-stranded RNA, and result in initiating innate immunity and regulating acquired immunity. All TLRs activate a common signaling pathway that culminates in the activa- tion of the mitogen-activated protein kinases （MAPKs） and nuclear factor-KB （NF-κB） transcription factors. Activating of MAP kinase signalling pathways regulate a range of cellular activities, including cell proliferation, differentiating and apoptosis . More and more researches demonstrated that MAP kinase kinase kinases （MAP3-Kinases） might have a more restricted ability to activate MAP kinase pathways. Here the progress in the research of specific MAP3-kinases that link TLR signal transduction pathway was discussed.
出处
《国际免疫学杂志》
CAS
2007年第5期308-311,共4页
International Journal of Immunology
