摘要
目的观察复方黄酮胶囊对大鼠长期毒性实验的影响。方法复方黄酮胶囊20.75,4.15 mg/kg(为临床日剂量的50倍和10倍)给大鼠连续灌服13周,停药2周,分别测量大鼠体重,计算脏器系数,测定血液学和血液生化学指标,并作组织病理学检查。结果复方黄酮胶囊高、低剂量组大鼠的外观体征、行为活动、体重,脏器系数,血液学和血液生化学指标,与空白对照组比较,均无明显差异;病理检查未见与药物毒性相关的明显病变,停药后也未见药物延迟性毒性反应。结论复方黄酮胶囊长期用药对大鼠无明显毒性,推论临床拟用剂量应是安全的。
Objective To observe the effects of Compound Flavone capsules on the rat chronic toxicity test. Methods 60 rats were randomly divided into 3 groups, each group was given Compound Flavone capsules intragastrically in dose of 20.75, 4.15 mg/kg （50 and l0 times of clinic dose） for 13 weeks. Half of the animals were killed immediately after the last dose, and another half of rats were observed for 2 weeks after medicine withdraw. Parameters examined included general condition, body weight, food intake, blood cell, blood biochemistry, organ index, and histopatbological exmination. Results The outer appearance and behavior, weights, organ coefficient, the indexes of haematology and biochemistry in rats had no significant difference by compa- ring with control group. The pathological examination did not discover significant pathological changes related to drug toxicity and the delayed toxicity reaction after drug administration. Conclusion Compound Flavone capsules have no significant toxicity for long - term administration on rats. It infers that the drawing up doses in clinic will be safe.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第9期2083-2085,共3页
Lishizhen Medicine and Materia Medica Research
基金
广西壮族自治区卫生厅计划课题(No.Z2003081)
关键词
复方黄酮胶囊
大鼠
长期毒性试验
Compound Flavone capsules
Rat
Long - term toxicity
