摘要
目的探讨窒息缺氧对新生儿血清瘦素(Lp)与血脂水平的影响。方法2004-03—2005-08对暨南大学第五附属医院52例窒息新生儿出生后第1天、第5天、第10天血清Lp、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(apoA1)及载脂蛋白B(apoB)进行测定,以32例健康新生儿作对照。结果窒息患儿生后第1天血清Lp水平[(4.06±3.02)ng/mL]显著低于对照组[(12.87±5.71)ng/mL](P<0.05),且随窒息程度加重而显著减少;窒息患儿TG[(0.76±0.47)mmol/L]、apoA1[(1.08±0.24)g/L]显著高于对照组,HDL-C[(0.69±0.40)mmol/L]显著低于对照组,均P<0.05。27例窒息患儿第5d与第1d相比,TC、LDL-C与apoB明显升高(P<0.05),而与第10d比较则无差异(P>0.05),HDL-C、apoA1到第10d明显升高,TG保持稳定。Lp水平与TC、TG、LDL-C、apoB的水平呈负相关(P<0.05),与apoA1、HDL-C无相关性(P>0.05)。结论窒息缺氧可导致新生儿瘦素与血脂代谢紊乱;瘦素可能参与了窒息新生儿血脂代谢紊乱的发病过程。
Objective To explore the influence of asphyxia on serum levels of Leptin and lipids in neonates. Methods The concentration of serum leptin and lipids including TC, TG, HDL-C, LDL-C, apoA1 and apoB were determined in 52 asphyxial neonates on day 1 ,day 5 and dayl0 and 32 normal neonates on day 1 after birth,respectively. Results Level of leptin in asphyxial neonates was significantly lower [ （4. 06 ± 3.02） ng/mL] than that [ （ 12.87 ± 5.71 ） ng/mL ] in normal neonates （ P 〈 0. 05 ）, and with a decreased trend following severity of asphyxia. The levels of TG [ （ 0.76 ± 0. 47 ） mmol/L] and apoA1 [ （ 1.08 ± 0. 24 ） g/L] increased and HDL-C [ （ 0. 69 ± 0.40 ） mmol/L] decreased in asphyxial neonates comparing to those in normal neonates （ P 〈 0. 05 ） for all. Furthermore, the levers of TC, LDL-C and apoB were higher on day 5 than those on day 1 after birth in 27 asphyxial neonates（ P 〈 0. 05 ） for all ,while no significant differents were observed between on day 5 and on day 10（ P 〉0. 05 for all）. The leverls of HDL-C and apoA1 increased evidently on day 10 and the level of TG kept stable. Serum leptin level had negatively correlatied with the levels of TC ,TG, LDL-C and apoB （ P 〈 0. 05 ） for all and not correlated with the levels of HDL-C and apoA （ P 〉 0. 05 for all ）. Conclusion Leptin and lipid disturbance can be induced by asphyxia in neonates. Leptin may involve in the pathogenesis of lipid disturbance in asphyxia neonates probably.
出处
《中国实用儿科杂志》
CSCD
北大核心
2007年第9期657-659,共3页
Chinese Journal of Practical Pediatrics
基金
广东省医学科研基金立项项目(编号:A2003832)
关键词
窒息
新生儿
瘦素
血脂
Asphyxia, neonate
Leptin
Lipid
