摘要
目的探讨模型动物的营养要求与饲养管理规范。方法利用人肝癌细胞系接种于BALB/c裸小鼠(nu/nu)建立人肝癌动物模型,从提高饲料营养成分和加强饲养管理入手,逐步控制了模型动物瘤体生长,为肿瘤学研究提供科学方法。结果改进了饲料营养和加强了饲养管理,模型动物的生存状况有了很大的改观,带瘤存活时间明显延长。结论饲料蛋白质营养的高低,可直接影响模型动物的生存质量和动物实验效果,对其他动物模型的建立有借鉴意义。
Objective To investigate the pattern feeding nutritional standard and breeding management of model animals. Methods In order to provide scientific method for oncology, the human liver cancer model was established by transplanted BALA/c nude mouse （nu/nu）, and the growth was controlled by enhancing nutritional component and strength the feeding management. Results By feeding up and enhancing, the tumor growth of model animals was controlled gradually and survival constitution of animal was improved remarkedbly, and the bearing tumor survival time was delivered obviously. Conclusion The protein nutrition of feed could impact on survival constitution and effect of animal experimental, this have the effective significantly for establishment of other animal method.
出处
《中国比较医学杂志》
CAS
2007年第9期523-525,共3页
Chinese Journal of Comparative Medicine
基金
甘肃省科技攻关项目(QS041-C33-33)
关键词
裸小鼠
模型
动物
饲养管理
Nude mouse
Model, animal
Breeding management
