摘要
目的观察大鼠多囊卵巢综合征(PCOS)动物模型血脂代谢及抗氧化作用的观察。方法建立PCOS大鼠模型,观察大鼠体重、动情周期、血清胆固醇(TC)、甘油三酯(TG),低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、瘦素、丙二醛(MDA)含量和超氧化歧化酶(SOD)活性的变化。结果显示PCOS大鼠血脂水平、瘦素水平,;丙二醛(MDA)含量均出现模型组显著性高于空白对照组。结论PCOS大鼠可引起血脂代谢紊乱,对抗氧自由基的氧化作用降低。
Objective To study the effects of the Lipid Metabolism and Anti-oxidation on PCOS rats. Method PCOS models were established using rats. The kind of animal model was used to observe body weight, estrous cycle, Lipid Metabolism, Leptin, SOD and MDA. Results Lipid Metabolism, leptin level and MDA was significantly higher in PCOS model group. Conclusion PCOS can cause dyslipidemia in rats, reducing the role of oxygen free-radical oxidation.
出处
《中国比较医学杂志》
CAS
2007年第9期519-522,共4页
Chinese Journal of Comparative Medicine
