摘要
为了研究Ｂｃｌ－２和ｐ５３基因蛋白与阴茎癌的关系，应用ＰＡＰ免疫组化法对４６例阴茎癌组织中Ｂｃｌ－２和ｐ５３基因蛋白进行检测。结果显示，正常鳞状上皮基底细胞Ｂｃｌ－２蛋白表达阳性，４６例阴茎癌中有３８例（８２．６％）Ｂｃｌ－２蛋白表达阳性，有１１例（２３．９％）ｐ５３蛋白表达阳性。提示两种癌基因蛋白的过度表达参与了阴茎癌的发生发展过程。
In order to study relationship between Bcl 2 and p53 protein expression and carcinoma of penis, PAP immunological method was used to detect Bcl 2 and p53 protein expression in penis carcinomas. The results showed that basal cell of the normal squamous epithelium were positive for Bcl 2 protein expression. In 46 cuses of penis carinoma, 38 cuses (82.6%) were positive for expression of the Bcl 2 protein. Expression of the p53 protein was found in 11 cases (23.9%). These datd suggest that overexpression of the Bcl 2 and p53 protein play a role in the development of penis carcinomas.
出处
《实用癌症杂志》
1997年第2期115-116,共2页
The Practical Journal of Cancer
