摘要
为探讨哌甲酯对吸气肌功能的影响，作者采用随机对照方法观察了７０例慢性阻塞性肺病（ＣＯＰＤ）患者静脉注射治疗剂量哌甲酯等药物前后最大吸气口腔压（ＭＩＰ）、最大吸气中段流量（ＭＭＩＦ）、用力深吸气量（ＦＩＣ）、最大吸气功（Ｗｉｍａｘ）、口腔阻断压（Ｐ０．１）及每分钟通气量（ＶＥ）等呼吸力学参数的变化，并与氨茶碱、可拉明比较。结果显示：用哌甲酯和氨茶碱后ＭＩＰ、ＭＭＩＦ、ＦＩＣ、Ｗｉｍａｘ、Ｐ０．１及ＶＥ均明显增加；用可拉明后Ｐ０．１增加更明显，但是反映吸气肌力的ＭＩＰ、ＭＭＩＦ、ＦＩＣ、Ｗｉｍａｘ参数却无明显变化。表明哌甲酯同氨茶碱一样，能明显增强ＣＯＰＤ患者的吸气肌功能。
To have a better understanding of the effect of methylphenidatum on inspiratory muscles function, we studied the respiratory force parameters of 70 patients with chronic obstructive pulmonary disease by intravenous infusion methylphenidatum in a randomized controlled clinical trial. The indices of respiratory force parameter included maximal inspiratory mouth pressure (MIP), maximal midinspiratory flow (MMIF), forced inspiratory capacity (FIC), maximal works of inspiration (Wi max ) and airway occlusion pressure (P 0.1 ), etc. Aminophylline and Nikethamidi were chosen as controls. The results showed that MIP, MMIF, FIC, Wi max , P 0.1 and minute ventilation (V E) were significantly increased after administration of methylphenidatum and aminophylline. There were no significent differences in MIP, MMIF, FIC and Wi max after administration of Nikethamidi, but P 0.1 was significantly increased and the increase was higher than that after administration of methylphenidatum and aminophylline groups. We conclude that methylphenidatum can significantly improve the function of inspiratory muscles as aminophylline can do.
出处
《华西医科大学学报》
CSCD
1997年第1期77-80,共4页
Journal of West China University of Medical Sciences
关键词
哌甲酯
吸气肌功能
阻塞性肺疾病
药物疗法
Methyphenidatum Function of inspiratory muscles Airway occlusion pressure Chronic obstructive pulmonary disease
