摘要
目的评价β-受体阻滞剂治疗老年慢性心力衰竭的疗效及安全性。方法107例老年慢性心力衰竭患者按就诊顺序随机分为两组，美托洛尔53例在常规抗心力衰竭治疗基础上加用美托洛尔12．5～25mg，2次／d；对照组54例采用常规抗心力衰竭治疗，来用荚托洛尔。定期来诊随访，以观察临床表现，监测治疗前后心率、血压、心功能参数变化。结果美托洛尔显效率53．7％，总有效率88．6％；对照组显效率30．3％，总有效率67．8％，两者比较有显著性差异（P〈0．0,5）。美托洛尔组患者心率减慢、血压降低较对照组明显，超声心动图复查显示治疗6个月后左室舒张末期内径缩小，左室射血分数增高较对照组显著。结论美托洛尔对老年慢性心力衰竭是一种较为安全有效的药物。
Objective To evaluate the clinical effect of metoprolol on elderly patients with chronic heart failure and its safety. Methods A total of 107 elderly patients with chronic heart failure were allocated into metoprolol group （ n = 53 ） and control group （ n = 54 ） at random. The patients in the metoprolol group were treated with metoprolol （ 12.5 - 25 mg, twice per day） and the pa- tients in the control group were only given routine treatment without metoprolol. The changes in heart rate, blood pressure, heart function and echocardiography were observed before and after treatment. Results The effective rate and total effective rate in the metoprolol group were 53.7% and 88.6% , and the counterparts were 30.3% and 67.8% in the control group, respectively （P 〈 0.05 ）. After the treatment lasting months, not only the heart rate and the blood pressure in the metoproiol group were lower than that in the control group, but the heart function and the indexes of echocardiography （LVEF, LVDD） were. obviously improved as well. Conclusion Metoprolol can served as an effective and safe agent for the treatment of the elderly patients with chronic heart failure.
出处
《临床军医杂志》
CAS
2007年第5期653-655,共3页
Clinical Journal of Medical Officers
