摘要
目的 了解中山大学第一附属医院近5年住院及门诊女性尿路感染致病菌菌群分布及耐药性情况，为临床合理使用抗生素提供依据。方法 选择2002年1月至2006年4月门诊及住院女性尿培养阳性的尿路感染患者，分析其细菌培养结果及对抗生素的耐药性。结果 共分离出876株病原细菌，革兰阴性菌占76．7％（672株），其中大肠埃希菌占49．2％（431株），肺炎克雷伯菌占7．9％（70株）；革兰阳性菌占23．3％（204株），其中粪肠球菌占7．5％（66株），屎肠球菌占5．4％（47株）。主要的革兰阴性菌及革兰阳性菌对喹诺酮类的耐药性均高达50％～80％以上，革兰阴性菌敏感的抗菌药包括亚胺培南、阿米卡星、头孢他啶、哌拉西林／他唑巴坦；革兰阳性菌敏感的抗菌药包括万古霉素、替考拉宁。结论 女性泌尿道感染仍以大肠埃希菌为主，耐药菌株不断增多，临床治疗应参考药敏结果合理选用抗菌药。
Objective To investigate the spectrum and antimicrobial resistance of pathogens causing urinary tract infection in female. Methods To analyze the spectrum and antimicrobial resistance of pathogens collected from urine cultures in female outpatients and hospitalized patients of urinary infections from January 2002 to April 2006. Results 876 positive cultures were isolated. Of them,Gram-negative bacteria accounted for 76.7%, with 49.2% of Escherrich＇s bacteria coli and 7.9% Klebsiella pneumoniae. Gram-postive bacteria accounted for 23.3%, with 7.5% of Enterococcus faecalis and 5.4% ofEnterococcus faecium. Resistance both of Gram-negative and Gram-positive bacteria to quinolones was over 50%～80%. The Gram-negative bacteria were sensitive to imipenm, piperaciUin/tazobactam, ceftazidime and amikacin,while the Gram-positive bacteria were sensitive to vancomycin and teicoplamin. Conclusions E. coli is still the major pathogen accounted for urinany tract infection in female. Resistancc rates among common pathogens appear to be increased to many common used agents. Drug - sensitivity test are needed to be taken into account when antibiotic therapy is used for urinary tract infection.
出处
《中国微生态学杂志》
CAS
CSCD
2007年第5期450-451,454,共3页
Chinese Journal of Microecology
关键词
泌尿道感染
菌群分布
耐药性
Urinary tract infections
Bacterial distribution
Antimicrobial resistance
