摘要
目的:分析超重及肥胖与脂肪肝的关系,探索肥胖与其他危险因素在脂肪肝发病中的交互作用。方法:选择2002-09/2004-12期间某社区人群,按分层多级整群抽样原则进行抽样调查,共调查2458例。根据1∶1配对病例对照研究的设计原理,选择其中确诊的425例脂肪肝患者作为研究病例,纳入标准:要求所有病例均有B超诊断报告,且年龄≥18岁,并从该人群的非脂肪肝患者中选择425例条件相似的作为对照,病例与对照在年龄、性别、居住地区方面均衡可比。对全体调查对象进行当面访谈调查和体格检查。结果:纳入调查对象850例,均进入结果分析。超重及肥胖者比正常体重者有显著升高的脂肪肝患病危险(OR=4.07,OR95%CI为2.99～5.54),OR值随体质量指数的增大而增大,呈明显的剂量反应关系(趋势χ2=104.25,P<0.0001)。腰臀比偏高的腹型肥胖者比非腹型肥胖者脂肪肝的发病危险更大。交互作用分析提示,肥胖与饮酒同时存在能显著增加疾病的危险性,其超额相对危险度为8.16,归因比为0.5767。结论:超重及肥胖与脂肪肝的发病关系密切,肥胖与饮酒在脂肪肝的发病中存在协同交互作用,控制体质量是降低人群脂肪肝患病率的重要措施。
AIM： To analyze the relationship of overweight and obesity with fatty liver, and explore the interaction of obesity and other nsk factors in the incidence of fatty liver.
METHODS： Totally 2 458 community residents were enrolled by means of stratified multistage cluster sampling between September 2002 and December 2004. According to 1：1 matched case-control study, this investigation adopted 425 cases diagnosed as fatty liver by B ultrasound and 425 controls matched by sex, age and inhabitancy. They aging over 18 years all received the personal interview and physical examination.
RESULTS： All 850 subjects were involved in the result analysis. The risks of the incidence of fatty liver in overweight and obesity group were significantly higher than that in normal body weight group （OR =4.07, OR 95%Cl=2.99-5.54）. The odds ratio （OR） increased with the body mass index, showing the clear dose-response relationship （Tendency Х^2=104-25, P 〈 0.000 1）. The disease risk of abdominal obesity persons with abnormal waist hip ratio was higher than those without abdominal obesity. Interaction analysis suggested that obesity plus drinking habit could significantly increase the risk of fatty liver. Its relative excess risk of interaction was 8.16, and its attributable proportion of interaction was 0.576 7.
CONCLUSION： There is a close relationship of overweight and obesity with the incidence of fatty liver, and a significantly synergistic interaction effect between obesity and drinking habit in developing fatty liver. The measurement to control the body weight is essential for decreasing the prevalence rate of fatty liver.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第39期7773-7776,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
重庆市科委科研资助项目(2003-7762)~~
