摘要
目的探讨国产雷帕霉素药物洗脱支架Firebird在急性ST段抬高心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)中应用的安全性和近、远期疗效。方法选择我院心内科2005年3月￣2006年6月收治的STEMI且在发病12h内接受急诊置入雷帕霉素药物洗脱支架的患者105例,分为Cypher组(33例)和Firebird组(72例)。比较2组住院期间和随访10个月时心脏事件(MACE)的发生率。结果Cypher组33例梗死相关血管的33处病变置入42枚Cypher支架,Firebird组72处梗死相关病变置入113枚Firebird支架。支架置入成功率为100%。无再流现象:Cypher1例,Firebird组2例(P=1.000)。Cypher组心脏破裂死亡1例,Firebird组亚急性支架内血栓形成死亡1例。住院期间MACE发生率Firebird组为1.4%(1/72),Cypher组3.0%(1/33)(P>0.1),临床PCI成功率91.4%(96/105)。对86例患者进行了平均[10.2±4.2(6￣20)]个月随访,Cypher组28例和Firebird组58例;再发心绞痛3例,Cypher组1例和Firebird组2例;Firebird组术后3个月心衰死亡1例;随访时MACE发生率:Firebird组3.4%(2/59),Cypher组3.4%(1/29)(P=1.000)。结论国产雷帕霉素药物洗脱支架Firebird在STEMI急诊PCI中应用安全有效,近、远期疗效与Cypher支架相近。
Objective To evaluate the safety and efficacy of Firebird drug eluting stent in primary percutaneous coronary intervention （PCI） for acute ST-segment elevated myocardial infarction （STEMI）. Methods From March 2005 to June 2006, a total of 105 patients with STEMI receiving sirolimus-eluting stents within 12 hours after symptoms onsetting were enrolled in this study,the patients were divided into two groups： Cypher group （33 cases）,and Firebird group （72 cases）. MACE was analyzed in-hospital and after 10 months followed-up in the two groups. Results 42 Cypher stents were implanted into 33 lesions in Cypher group ,compared with 113 Firebird stents into 72 lesions in Firebird group. The procedure success rate was 100%. No reflow phenomenon occurred in 2 cases in Firebird group and 1 case in Cypher group （P=1.000） . 1 Patient in Cypher group died of rupture of the heart , 1 patient died of suba- cute-thrombosis in Firebird group .The rate of in-hospital MACE in Firebird group was 1.4%, compared to 3.0% in Cypher group （P〉0.1）. 96 patients were successfully treated by PCI. ,the success rate was 91.4%.86 patients were followed up for 6 to 20 months （ 10.2 ＋ 4.2）. Angina pectoris occurred in 1 patient in Cypher group and 2 patients in Firebird group ;1 patient died of heart failure in Firebird group . After 6-20 months followed-up, the rate of MACE of in Firebird group was 3.4%, compared to 3.4% in Cypher group（P=-1.000）.Conclusion Implanting of Firebird drug eluting stent in STEMI patients receiving emergency PCI was as safe and effective as that of Cypher drug eluting stent.
出处
《基层医学论坛》
2007年第9期773-776,共4页
The Medical Forum
关键词
急性心肌梗死
雷帕霉素药物洗脱支架
介入治疗
Acute myocardial infarction Sirolimus-eluting stent Interventional treatment
