摘要
目的：观察异丙酚不同浓度时在不同时间对乳头肌收缩性能的影响并和咪唑安定进行比较。方法：２０条乳头肌随机分成２组，分别给予异丙酚１０、２０、３０、４０μｇ／ｍｌ和咪唑安定１０、２０、５０、１００μｇ／ｍｌ，观察等长张力峰值（ＰＴ），张力上升最大速度（ｄＴ／ｄｔｍａｘ），张力下降最大速度（－ｄＴ／ｄｔｍａｘ）和心肌收缩成份的缩短速度（Ｖｃｅ）在用药后的变化。结果：当异丙酚的浓度达到４０μｇ／ｍｌ，作用时间达到９．５±１．５８分，咪唑安定的浓度达到１００μｇ／ｍｌ，作用时间达到１４．５±１．５８分时即可完全抑制心肌收缩，两药在浓度和作用时间上均有显著差异（Ｐ＜０．０５）。结论：对于离体的ＳＤ大鼠乳头肌，异丙酚比咪唑安定产生的负性肌力作用更大。
Objective:To evaluate the effects of various concentrations of propofol and midazolam at various time on myocardial contraction Method:Twenty left ventricular papillary muscles in vitro were randomly divided into two groups(group P and group M) The contractility parameters were measured such as peak twitch tension(PT),maximum rate of contraction(dT/dt max ),maximum rate of relaxation(-dT/dt max )and velocity of shortening of myocardial muscle contractility element(Vce) The concentrations were 10,20,30,40 μg/ml of propofol and 10,20,50,100μg/ml of midazolam The changes of myocardial contractility were observed at 2,5,10,15 min after the virous concentration administration Result:The complete inhibition occurred when the concentration of propofol was 40 μg/ml and lasted 9 5±1 58 min while midazolam was 100 μg/ml and 14 5±1 58 min The differences were statistically significant in time and concentration between propofol and midazolam (P<0 05) Conclusion:Propofol is a more potent myocardial depressant than midazolam
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1997年第5期286-288,共3页
Chinese Journal of Anesthesiology
关键词
异丙酚
大鼠
乳头肌
收缩性能
Propofol Rat papillary muscle Myocardial contraction Midazolam
