摘要
目的观察乳癌改良根治术术中氟比洛芬酯的镇痛效果，探讨氟比洛芬酯超前镇痛的有效性。方法择期全麻下行乳癌改良根治术的患者60例，ASAⅠ或Ⅱ级，年龄37～65岁，随机分为3组每组各20例：瑞芬太尼组（Ⅰ组）、氟比洛芬酯术前给药组（Ⅱ组）、追加给药组（Ⅲ组）。术中监测各组患者的血流动力学；采用模糊视觉疼痛评分（VAS）法，对术后患者清醒拔管后10min、回病房后2、6、12及24h进行疼痛评分，并记录术后各组患者使用镇痛药物的次数及用药总量。结果Ⅱ组和Ⅲ组同Ⅰ组相比术中血流动力学的改变差异无显著性；Ⅱ组和Ⅲ组术后使用镇痛药的次数和药量明显少于Ⅰ组。结论在乳癌改良根治术术中氟比洛芬酯可能有一定的镇痛效果；氟比洛芬酯的超前镇痛作用在乳癌改良根治术中能够确定。
Objective To observe the analgesic effects of flurbiprofen axetil in modified radical mastectomyon. Methods Sixty ASA Ⅰ or Ⅱ patients （age range 37 - 65 yrs） undergoing elective modified radical masteetomy were randomly allocated into 3 groups （ n = 20 in each group） ： group Ⅰ remifentanil （ Ⅰ ） ; group Ⅱ flurbiprofen axetil （Ⅱ）, group, m fluebiprofen axetil boosting （Ⅲ）, Noninvasive BP and HR were recorded during the operation. Postoperative pain scoring was performed after patients returned the ward and at 2, 6, 12,24 hours postoperatively. The total administration dose and frequency were recorded. Results There was no significant difference in the changes of hemodynamics between group Ⅰ and group Ⅱ as well as group Ⅲ ; the total adminastration dose of analgesic drugs and frequency in group Ⅱ and group Ⅲ were obviously lower than those in group Ⅰ . Conclusion Flurbiprofen axetil may has a certain analgesic affect during modified radical mastectomy, and which might have a preemptive analgesic effect.
出处
《河北医药》
CAS
2007年第7期674-675,共2页
Hebei Medical Journal
关键词
氟比洛芬酯
乳癌改良根治术
术中镇痛
超前镇痛
flurbiprofen axetil
modified radical mastectomy
operative analgesia
preemptive analgesia
