摘要
本文根据“七五”期间在大肠癌高发区浙江省嘉善县进行的大肠癌人群序贯筛检资料，对原方案作进一步的修正，制订出优化方案并用两种筛检方案对该地区６４６４０人群进行回代验证。结果显示：在大肠新生物组，用序贯筛检方案检出新生物２７０例（２７０／４０７），敏感度为６６．３％，特异度９５．５％，正确指数０．６２；而用优化方案，可检出大肠新生物３５２例（３５２／４０７），敏感度为８６．５％，特异度为８６．０％，正确指数０．７３，经χ２检验，二组具有非常显著的差异（Ｐ＜０．０１）。此外，优化筛检方案方便简单，能迅速得出复筛的范围，适合于大规模的人群筛检、基层医院及医疗条件较差的机构开展大肠新生物的初筛。
Based on the data of screening for colorectal cancer in high incidence area,Jiashan county Zhejiang province,we modified and finalised the sequential screening program and established an optimized protocol.The optimized protocol was tested in a screened population of 64640 in Jiashan county.The results showed that using optimized protocol 352 out of 407 of colorectal neoplasm could be detected,a sensitivity was 86 46%,specificity was 85 99% and Younden index was 0 73 higher than that of sequential screening protocol 0 62(sensitivity was 66 33%,specificity was 95 48%).The difference was statistical significant( P <0 01).The optimized protocol appears simpler,less time consuming,and more resource saving than conventional sequential protocol,so the authors suggest that the optimized protocol could be most suitable for screening in large population particularly for grass roots level health institutions.
出处
《中国慢性病预防与控制》
CAS
1997年第2期75-76,84,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
基金
国家"八五"科技攻关课题
关键词
大肠肿瘤
癌
筛检方案
优化方案
人群筛检
Colorectal neoplam\ Saquential protocol\ Optimization\ Population screening
