摘要
为评价高压氧对新生儿缺氧缺血性脑病（HIE）的疗效，尤其是远期效果，采用随机对照方法，对53例中，重度HIE病例进行了治疗研究，存活病例随访至1～7岁。治疗组27例，对照组26例，两组均给予综合治疗，治疗组加用高压氧。结果表明，治疗组神经系统症状消失天数短于对照组（t=3．654，P＜0．001）。预后：治疗组重度7例，死亡2例，轻度脑瘫1例，正常4例；对照组重度5例，死亡3例，智力低下2例，无1例正常。中度两组均无死亡及后遗症发生。研究结果提示，高压氧可缩短HIE患儿病程，对减少后遗症可能有帮助，在合理治疗下是安全的，是治疗HIE的一种很有希望的方法。
To evaluate therapeutic effects of hyperbaric oxygenation (HBO) in treatment of neona tal hypoxic ischemic encephalopathy (HIE), the authors applied randomized controlled method to conduct the present clinical study in 53 infants with moderate and severe HIE, and followed up the living patients up to 18 months to 7 years of age. The treatment group con sisted of 27 infants and the control group 26 infants. They were all administered corticos teroid, supporting and symptomatic therapy. The infants in treatment group were added HBO. The results of the study showed that number of days needed for disappearance of neu rological symptoms and signs in treatment group was less than that in control group. (t=3.654, P＜0.001) Prognosis: of 7 infants with severe HIE in treatment group, 2 died, I has mild cerebral palsy, 4 are normal of 5 cases with severe HIE in control group, 3 died, 2 were mentally retarded, none is normal. Patients with moderate HIE in both groups have no death and sequelae. We conclude that HBO can shorten the duration of syrnptoms of HIE and re duce its sequelae. It is a hopeful treatment for HIE
出处
《新生儿科杂志》
1997年第1期13-15,共3页
The Journal of Neonatology
