摘要
目的了解百优解分散片与中枢神经兴奋剂利他林治疗儿童注意缺陷多动障碍(ADHD)的疗效及副反应。方法33例ADHD随机分为观察组和治疗组,进行一般观察,于治疗前用多动指数量表(CIH)评定。百优解分散片与利他林均于1周内达到治疗量,并持续6个月。结果两组治疗后多动指数量表(CIH)CornnerRs部分均显著下降,两组治疗后CornnerRs评分与治疗前相比,部分有统计学意义(P<0.05);两组治疗后CornnerRs评分比较,差异无统计学意义(P均>0.05),显示两种药物的疗效相仿。两组的不良反应症状量表TESS总分分别为(0.4±0.4)分和(1.4±0.9)分,百优解分散片组TESS部分显著低于利他林组(P<0.05)。结论百优解分散片组副反应轻,耐受性好,依从性高,起效快,因而对于ADHD,百优解分散片值得临床研究。
Objective To study the curative effects and the side effects of Fluoxetine Hydrochloride and Methylphenidate in treatment of attention deficit hyperactivity disorder （ADHD）. Method 33 cases of confirmed ADHD were divided into the observation group and treatment group. Patients were treated with Fluoxetine Hydrochloride or Methylphenidate with a dose reached the treatment quantity in 1 week, and then continued for 6 months. The patients were evaluated before and after treatment with Conners Index of Hyperactivity （CIH）. Result Some parameters of Conners Index of Hyperactivity （CIH） were decline after treatment in the two groups. Comparisons the two groups before and after treatment, there were no obvious differences in the Conners＇ Index （P 〉 0.05）, indicating that two kinds of medicines showed similar curative effect. The TESS total scores, indicating the adverse effect, of the observation group and treatment group were （0.4±0.4） and （1.4±0.9）, respectively. The partial score of TESS in patients treated with Fluoxetine Hydrochloride treatment group was remarkably lower than that in patients treated with Methylphenidate （P〈 0,05）. Conclusion Fluoxetine Hydrochloride treatment showed a mild side effect, good tolerance, high compliance and quick response.
出处
《热带医学杂志》
CAS
2007年第8期770-771,794,共3页
Journal of Tropical Medicine
