摘要
目的研究腹腔化疗对进展期胃癌术后早期应用的临床疗效。方法1998年1月至2002年12月的80例进展期胃癌患者行胃癌根治术后,早期应用皮下置入式化疗泵行腹腔化疗(IPC)的病例进行回顾性分析,并与同期行静脉化疗(IVC)的80例患者进行分析比较。结果80例腹腔化疗病人(治疗组)和80例静脉化疗病人(对照组)均完成全部6个疗程的化疗,治疗组腹腔转移率、肝转移率和血清肿瘤标记物水平明显低于对照组,3年生存率为70.5%,5年生存率为54.8%,高于静脉化疗组(42.4%,36.7%,P<0.05)。结论进展期胃癌患者术后早期行腹腔化疗,药物的毒副反应小,可以提高胃癌术后病人的生存率和生存质量。
Objective To evaluate effects of early postoperative intraperitoneal chemotherapy （IPC）on advanced gastric cancer. Method From Jan. 1998 to Dec. 2002, 80 patients with advanced gastric cancer were treated with IPC after radical operation in our hospital. The results of treatments were compared with 80 cases with intravenous chemotherapy （IVC）. Result 80 patients in the IPC group and IVC group received all the 6 phases of chemotherapy. Compared with IVC, the IPC treatment has advantages of lower metastasis rate, lower hepatic metastasis rate, lower level of CEA and CA19-9. The 3-year survival rate （70.5%）, 5-year survival rate （54.8%） in the IPC treated patients were higher than those in IVC treated patients （42.4% and 36.7%, respectively, P〈0.05）. Conclusion For patients with advanced gastric cancer, treatment with IPC at the early postoperation period after radical operation has less side effect, higher survival rate and better life quality.
出处
《热带医学杂志》
CAS
2007年第8期763-765,共3页
Journal of Tropical Medicine
关键词
胃癌
腹腔化疗
静脉化疗
腹腔种植
生存率
gastric cancer
intraperitoneal chemotherapy
intravenous chemotherapy
peritoneal metastases
survival rate
