摘要
破骨细胞(Osteoclast OC)来源于单核/巨噬细胞谱系,其数量和活性的不足或增加分别会导致骨硬化症和骨质疏松及其他溶骨性疾病。为了更好的理解这些疾病的发病机理和制定相关治疗方案,我们就必须揭示破骨细胞的分化调节机制。笔者将就破骨细胞在分化过程中的信号通路及其调节因素以及一些潜在可行的治疗骨量丢失相关疾病的方法予以综述。
The osteoclast is a member of the monocyte/maacrophage family, decreased or increased number and activity of osteoclasts respectively causes osteopetrosis or osteoporosis and other osteolytic diseases. To better understand the mechanisms underlying osteoclast-based diseases and design relevant therapies, one should unveil the molecular basis of osteoclast differentiation. This review will outline up-to-date information regarding the signaling pathways and the regulating factors of osteoclast differentiation and some potential therapies that aim at curing the osteolytic diseases.
出处
《中国骨质疏松杂志》
CAS
CSCD
2007年第8期600-603,共4页
Chinese Journal of Osteoporosis
关键词
破骨细胞
分化
调节
骨质疏松
Osteoclast
differentiation
regulation
osteoporosis
