摘要
检测了急性缺血性脑血管病患者４２例和对照组３０例的脑脊液超氧化物岐化酶（ＳＯＤ）、丙二醛（ＭＤＡ）含量。病例组ＭｎＳＯＤ和ＭＤＡ含量均显著高于对照组（Ｐ＜０．００１），ＣｕＺｎＳＯＤ含量轻型患者高于中、重型患者，短暂性脑缺血发作患者高于对照组和梗塞组，而且与患者神经功能缺损积分呈显著性负相关。缺血性脑血管病急性期患者脑脊液ＳＯＤ的增高反映了脑组织对缺血的防御反应，尤其是ＣｕＺｎＳＯＤ对缺血比较敏感，可以反映出神经功能损伤的程度。
The superoxide dismutase(SOD) and malondialdehyde(MDA) levels in cerebrospinal fluid(CSF) were measured in 42 patients with ischemic cerebrovascular disease(ICVD) and 30 normal controls. The results showed that MnSOD and MDA levels in CSF of patients with ICVD were significantly higher than normal controls( P <0.001).CSF CuZnSOD levels in mild cases was higher than in middles and severes,that was also higher in patients with transe ischemia attack than in patients with infarction and in normal controls.Negative correlation between CSF CuZnSOD level and neurologic defecit scoles was confirmed.An elevated CSF SOD level predicted a protective response of brain to ischemic.The change of CSF CuZnCOD level is responsive to ischemic and that could predict the degrees of neurologic dysfunction.
出处
《临床神经病学杂志》
CAS
1997年第1期9-11,共3页
Journal of Clinical Neurology
