摘要
用流式细胞技术（FCM）分别对41例直肠癌新鲜标本的癌灶、癌远端（2cm）移行区及近切缘正常组织进行细胞动力学研究。结果：癌灶SPF和PI极显著高于癌远端2cm移行区及近切端正常组织（P＜0．01）。癌远端2cmSPF显著高于近切端组织（P＜0．05），说明癌旁2cm组织的DNA合成期细胞已呈增殖活跃状态，尽管普通光镜下此区尚无癌细胞。结论：直肠癌远端2cm作为切除的距离并不安全，提示直肠癌远端切除距离不够可能是术后复发的重要因素之一。
Flow cytometry (FCM )techniques were used in this study done on 41 fresh radical surgical specimens of rectal carcinoma. Materials for study were taken respectively from lesion,tissues 2cm off the lower margin of lesion and normal tissue beyond 2cm off the proximal margin of the fresh unpinned specimen. The synthetic phase cells (SPF) and proliferative index (PI) of the cancer fool were significantly higher than those in tissues within and beyond 2cm of cancer margin especially distally (P<0. 05). In conclusion, 2cm distal margin of resection is unsafe and may account for one of the causes of recurrence
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1997年第5期343-346,共4页
Chinese Journal of Clinical Oncology
