摘要
为了解小儿腹泻时的蛋白质营养状况，用氨基酸自动分析仪测定了61例腹泻患儿的16种血清游离氨基酸浓度。结果显示，急性腹泻时除苯丙氨酸外均下降，但苏、丝、甘、半胱、脯氨酸差异无显著性；慢性腹泻时16种氨基酸均下降，除谷、蛋、丝、甘、半胱、脯氨酸外均有显著性；急、慢性腹泻时BCAA、TEAA、TAA、TNEAA均下降，而GLY／VAL比值上升（P＜0.05）。慢性腹泻时7种必需氨基酸：苯丙、苏、缬、异亮、亮、赖、组氨酸，及TEAA／TNEAA和TEAA／TAA比值下降的程度比急性腹泻时严重（P＜0．05）。提示小儿急、慢性腹泻时均存有蛋白质营养不良，慢性腹泻者程度更为严重。
To investigate the protein nutritional condition in infantile diarrhea, the serum levels of 16amino acids were measured in 61 cases of diarrhea by the automatic amino acid analyser. The result showed that 15 serum amino acids reduced during acute diarrhea except for PHE,but no significant difference was found in THR, SER, GLY, CYS, PRO. In chronic diarrhea, all the 16serum amino acids decreased and showed statistical significance except for GLU, MET, SER,CYS, GLY and PRO. BCAA, TEAA, TNEAA, TAA reduced greatly both during acute and chronic diarrhea, while the GLY/VAL ratio increased distinctly. 7 essential amino acids: PHE,THR, VAL, ILE, LEU, LYS, HIS and the ratio of TEAA/TNEAA, TEAA/TAA reduced much more heavily in chronic diarrhea compared with those in acute diarrhea. Our study suggested that protein malnutrition was present not only in acute diarrhea but also in chronic diarrhea,especially in the latter.
关键词
腹泻
诊断
氨基酸类
血清
婴儿
Diarrhea,infantile/diag
Amino acids/blood
