摘要
目的：研究脑室注射α干扰素（ＩＦＮ－α）对脾交感神经活动的影响及其影响途径．方法和结果：用ｕｒｅｔｈａｎｅ和α－ｃｈｌｏｒａｌｏｓｅ麻醉ＳＤ大鼠，第三脑室微量注射基因重组人ＩＦＮ－α３×１０４Ｕ，观察到脾交感神经冲动数增加．这种作用可被阿片受体阻断剂纳洛酮（Ｎａｌ）（１ｍｇ／ｋｇ）所翻转，但单独应用Ｎａｌ对脾神经兴奋性没有影响．实验中未观察到ＩＦＮ－α和Ｎａｌ对体温和动脉血压有影响．结论：ＩＦＮ－α可以在中枢神经系统通过由阿片受体介导的通路增强脾交感神经的电活动．
Objective: To study the effect of central administration of interferon α (IFN α) on the splenic sympathetic nerve activity. Methods: IFN α (3×10 4 U/rat) was microinjected into the third cerebroventricle of urethane and α chloralose anesthetized rats. Electricity activity of the splenic nerve, body temperature and blood pressure were determined simutaneously. Opioid antagonist naloxone (1 mg/kg, Ⅳ) was used in some groups. Results: Central administered IFN α elicited a marked and long term (>120 min) increase in the splenic nervous activity, which could be reversed by following naloxone treatment. No changes in blood pressure and body temperature, which can alter the sympathetic nerve activity by reflexation, were observed during IFN α and naloxone treatment. Naloxone intravenous injection alone had no effect on the splenic nervous activity. Conclusion: IFN α in the brain can activate the splenic sympathetic nerve, and this action is, in some way, mediated by the opioid receptor.
出处
《第四军医大学学报》
1997年第3期238-240,共3页
Journal of the Fourth Military Medical University
关键词
干扰素
交感神经系统
脾神经
脾脏
免疫调节
injections, intraventricular interferon α spleen sympathetic nervous system naloxone
