摘要
目的分析儿童肾上腺肿瘤的临床特征,提高对儿童肾上腺肿瘤诊断和处理的认识。方法回顾分析1991—2002年12年间中山大学附属第一医院收治的104例儿童肾上腺肿瘤的临床特点、诊断和病理的关系。结果发病年龄0～14岁,男63例,女41例。神经母细胞瘤75例;肾上腺皮质肿瘤22例,其中癌及腺瘤各11例;嗜铬细胞瘤2例;其他5例。神经母细胞瘤患儿以发热、腹痛、腹部包块为主要表现,尿香草杏仁酸(VMA)可不升高;肾上腺皮质肿瘤患儿中外周性性早熟的临床及内分泌激素改变多于库欣综合征表现。血乳酸脱氢酶(LDH)水平对鉴别良/恶性肿瘤有提示意义。结论儿童肾上腺肿瘤以神经母细胞瘤及肾上腺皮质肿瘤最为常见,临床表现异于成人,应结合临床及影像学特征综合诊断。
Objective To analyze the clinical manifestation of pediatric adrenal tumors and enhance the knowledge of diagnosis and treatment. Methods A retrospective study was carried out in 104 children with adrenal tumors. We analyze the relationship between clinical characteristics, diagosis and pathology. Results The incidental age was 0 - 14yr. A total of 104 children include 63 boys and 41 girls,75 being neuroblastoma,22 adenocortical tumor（ half were adenocacinoma and half were adenoma ） ,2 pheochromocytoma, and 5 others. The major clinical manifestation of neuroblastoma was fever, stomachache and palpable abdominal mass. The urine VMA is not necessarily to elevate in every case. Periphery sexual precosity was more common than Cushing syndrome in children＇s adenocortical tumor. Blood LDH level was one of the hints to differentiate the malignancy from the benign tumor. Conclusion The most common adrenal tumor in children is neuroblastoma and adenocortical tumor. The clinical manifestation is different from adults. Diagnosis should be made according to the clinical manifestation and the image characteristic.
出处
《中国实用儿科杂志》
CSCD
北大核心
2007年第8期606-608,共3页
Chinese Journal of Practical Pediatrics
