摘要
煤焦沥青作业工人外周血淋巴细胞微核率及染色体畸变率调查结果发现:细胞微核检出率和染色体畸变率接触者均高于非接触者,差异有显著意义(P<0.05)。实验和调查证实煤焦沥青对人体有致突变作用。29例染色体与微核检测的配对卡方检验,X^2=5.06,P<O.01,表明微核检测方法不及染色体畸变分析灵敏。
The results showed that both the rate of chromosome aberration and the rate of micronucleus in the gaseous coal tar pitch exposed group were obviously higher than those in the non-exposed group.The difference between the two groups was significant (P<0.05) .The results of this investigation indicated that coal tar pitch may induce mutagenic effect on workers.The chi-square value from match of chromosome aberration and micronucleus for 29 cases was 5.06 (P<0.01) , it Suggested that the micronucleus test is more sensitive than chromosome aberration analysis.
出处
《工业卫生与职业病》
CAS
CSCD
1990年第6期339-341,共3页
Industrial Health and Occupational Diseases
关键词
煤焦沥青
细胞遗传学
致突变试验
coal tar pitch
chromosome
micronucleus
mutagenic test
