摘要
研究持续气道正压通气(CPAP)对阻塞性睡眠呼吸暂停综合征(OSAS)小型猪睡眠生理的影响。12只成年雄性小型猪随机分为A、B两组,均予22d、6h/d间歇性低压低氧处理。之后A组再给予30d、6h/d的CPAP治疗,B组饲养30d。低压低氧处理及CPAP治疗后,均行睡眠监测、咽部吸气负压检查。由软件得出呼吸暂停低通气指数(Apnea hypopnea index,AHI)、呼吸暂停指数(Apnea index,AI)、低通气指数(Hypopnea index,HI)、平均血氧饱和度(SpO2)。A组CPAP治疗后较治疗前AHI、AI均显著减少(P<0.05);而SpO2显著提高(P<0.05);HI无显著改变。A组CPAP治疗后AHI、AI、HI均显著低于B组(P<0.05);SpO2则显著高于B组(P<0.05)。B组饲养30d前后AHI、AI、HI、SpO2无显著差异。A组CPAP治疗后咽部吸气负压较治疗前显著降低(P<0.05),并低于B组(P<0.05);B组30d后吸气负压增大(P<0.05)。结果提示CPAP治疗可显著改善OSAS小型猪的睡眠生理学指标。
To study the effect of continuous positive airway pressure （CPAP） on sleep physiology of mini pigs with obstructive sleep apnea syndrome（OSAS） induced by altitude hypoxia, 12 adult male mini pigs were randomly assigned into 2 groups, named A and B. The mini pigs in group A were treated with altitude hypoxia 6 h per day for 22 days, and then with CPAP 6 h per day for 30 days. For comparison, the mini pigs in group B were treated with altitude hypoxia only. The test of inspiration pressure of pharyngeal portion and the monitoring of sleeping were performed after the treatments of altitude hypoxia and CPAP. The sleeping monitor recorded the movements of chest and abdomen, respiratory airflow, heart rate, and pulse oxygen saturation （SpO2）. The Apnea/Hypopnea Index （AHI）, Apnea Index （AI）, Hypopnea Index（HI）, average SpO2 were all derived from the data of sleeping monitoring. In group A, the AHI and AI decreased after CPAP treatment; in the same time, SpO2 increased; these changes were significant （P〈0. 05）. The HI showed no significant change after CPAP treatment. The AHI, AI and HI of group A after CPAP treatment were significantly lower than those of group B after altitude hypoxia treatment only, and the SpO2 of group A was higher than that of group B. The pharyngeal inspiration pressure of group A was significantly decreased after CPAP treatment and was significantly lower than that of group B. All in all,the findings suggested that CPAP treatment could normalize the physiological indices of sleeping.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2007年第4期862-865,共4页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(30370378)
关键词
持续气道正压通气
阻塞性睡眠呼吸暂停综合征
动物模型
睡眠监测
睡眠生理
Continuous positive airway pressure（CPAP） Obstructive sleep apnea syndrome（OSAS） Animal model Sleep monitoring Sleep physiology
