摘要
目的通过动态监测血清心型脂肪酸结合蛋白(H-FABP),研究使用国产封堵器进行儿童心导管介入治疗后心肌损伤的情况。方法随机选取先天性心脏病(先心病)介入治疗的患儿30例,动态监测H-FABP的变化。结果30例先心病患儿血清H-FABP术后15min升高达峰值,术后4h开始下降,24h基本恢复。术前及术后5～15min、4h、24h分别为(1.28±0.19)ng/ml、(8.51±1.82)ng/ml、(2.31±0.58)ng/ml、(0.87±0.17)ng/ml,各时间点差异有统计学意义(P<0.01)。结论先心病介入治疗存在心肌微小损伤,H-FABP是早期判断心肌损伤的良好指标,测量H-FABP可为临床防治术后并发症提供科学依据。
Objective Through monitoring the changes of heart fatty acid-binding protein （H-FABP）, to investigate myocardial damage degree in children with congenital heart diseases during cardiac catheterication by using domestic occluder. Methods Thirty children with congenital heart diseases undergoing cardiac catheterication were randomly divided into three groups, and their serum levels of H-FABP were measured at four time points from preoperative day to next day. Results The serum H-FABP concentrations at 15min before and after the operation,at 4h and 24h were （ 1.28 ±0. 19 ） ng/ml, （8.51 ± 1.82 ） ng/ml, （ 2.31 ± 0.58） ng/ml, （ 0.87± 0.17） ng/ml respectively, there were significant differences among the four time points （ P 〈 0.01 ）. Conclusion The intervention therapy for congenital heart diseases might result in slight injury on myocardium, and serum H-FABP is an early and sensitive marker for predicting myocardial injury, and the detection of H-FABP could provide scientific basis for preventing the complications after the operation.
出处
《疑难病杂志》
CAS
2007年第8期457-459,共3页
Chinese Journal of Difficult and Complicated Cases
基金
河北省医学科学研究重点课题计划(编号05158)
关键词
心脏病
先天性
介入治疗术
心导管
脂肪酸结合蛋白
心肌型
儿童
Heart diseases, congenital
Intervention therapy, cardiac catheter
Fatty acid-binding protein,myocardial type
Children
