摘要
目的 探讨河南地区汉族人群乙型肝炎e抗原阳性慢性乙型肝炎遗传易感性与人类白细胞抗原DRB1等位基因多态性的关系。方法 应用聚合酶链反应-序列特异性引物技术，对河南汉族38例乙型肝炎e抗原阳性慢性乙型肝炎患者及42例正常健康人进行了HLA—DRB1^＊ 1201／1202、^＊1501／1502等位基因检测，应用统计学软件SPSS10．0对两组实验结果进行X^2检验。结果 两组的HLA—DRB1^＊1201／1202、^＊1501／1502等位基因频率差异无统计学意义。结论 HLA—nRR1^＊1201／1202、1501／1502等位基因与乙型肝炎e抗原阳性慢性乙型肝炎的形成无相关性。
Objective To study the association of HLA - DRB1 allele polymorphism with the genetic susceptibility to chronic hepatits B （CHB） of HBeAg positive. Methods Thirty - eight patients with CHB of HbeAg positive in Henan were investigated for HLA - DRB1 ^＊ 1201/1202, ^＊1501/1502 alleles by polymerase chain reaction - sequence specific primers（ PCR - SSP） technique. The results were compared with those from 42 normal healthy people by use of X^2 - test of Microsoft SPSS 10.0. Results The frequencies of HLA - DRB1^＊ 1201/1202, ＊^1501/1502 alleles in patient group were not significantly different compared with the frequencies in control group. Conclusion HLA - DRB1 ^＊1201/1202, ^＊1502/1502 alleles have no association with CHB of HbeAg positive patients in Henan Han nationality.
出处
《中原医刊》
2007年第15期13-14,共2页
Central Plains Medical Journal
关键词
人类白细胞抗原DRB1等位基因
乙型肝炎e抗原阳性
慢性乙型肝炎
遗传易感性
Hunman leukecyte antigen DRB1 allele
HBeAg positive
Chronic hepatitis B
Genetic susceptibility
Yolymerase chain reaction- sequence specific primers
