摘要
目的:观察急性冠脉综合征患者血小板膜连蛋白Ⅴ(AnnexinⅤ)及P选择素(CD62p)的变化及其临床意义。方法:流式细胞术(FCM)检测78例冠心病患者及26例健康体检者血小板膜AnnexinⅤ和CD62p的阳性百分率。结果:冠心病组AnnexinⅤ表达率与对照组相比,显著性升高(P<0.01),不稳定型心绞痛组及心梗组与对照组相比,CD62p表达率显著性升高(P<0.01)。心梗组和不稳定型心绞痛组与稳定型心绞痛组比较,AnnexinⅤ及CD62p表达率均有显著性差异(P<0.01)。结论:测定血小板AnnexinⅤ和CD62p对急性冠脉综合征患者的诊断有重要意义。
Objective： To explore the changes of Annexin Ⅴand CD62p on platelet in patients with acute coronary syndrome.Methods： The positive rates of Annexin Ⅴand CD62p in 78 patients with coronary heart disease（CHD） and 26 healthy controls were analyzed by flow cytometry（FCM）. Results： The percentage of Annexin Ⅴ expression on the platelet in patients with CHD was higher than that of healthy controls（P〈0.01）,and CD62p expression in patients with unstable angina and acute myocardial infarction（AMI） was also higher than that of healthy controls（P〈0.01）.The percentage of Annexin Ⅴ and CD62p expression on the platelet in patients with AMI and UA was higher than that of patients with stable angina（P〈0.01）. Conclusion： The changes of Annexin Ⅴand CD62p on the platelet of patients with acute coronary syndrome had significant value.
出处
《江苏大学学报（医学版）》
CAS
2007年第4期348-350,共3页
Journal of Jiangsu University：Medicine Edition
