摘要
目的:检测贲门腺癌组织中内皮抑素表达水平与贲门腺癌临床病理特征的关系。方法:应用免疫组化染色SP法分析62例贲门腺癌患者肿瘤组织中内皮抑素的阳性表达水平。结果:内皮抑素表达水平与贲门腺癌原发肿瘤的浸润深度、细胞分化程度、临床TNM分期均有密切关系(P均<0.05),而与区域淋巴结转移状态无明显关系(P>0.05);多因素相关分析发现内皮抑素阳性表达水平与原发肿瘤侵润深度、临床TNM分期均呈负相关(P均<0.05),与细胞分化程度呈正相关(P<0.05)。结论:内皮抑素的表达水平与贲门腺癌临床病理分期、浸润深度及细胞分化程度有相关性,而与区域淋巴结转移状态无明显关系。
Objective： To analyze the expression of endostatin and its relationship with clinical pathology characteristics in eardia gland cancer. Method： We analyzed the endostatin expression levels in tissues from 62 eardia disease patients by applying immunolaistochemical staining （SP method）. Result： The expression of endostatin in cardia gland cancer was closely related to the degree of invasion of the primary tumor, clinical TNM grade and cellular differentiation of eardia gland cancer （P〈0.05）, but not to metastatic spread to local lymph nodes （P〉0.05）. The mutivariable analysis showed that the expression of endostatin is negatively correlated with the degree of invasion of the primary tumor and the clinical TNM grade （P〈0.05）, and it is pnsitively correlated with cellular differentiation （P〈0.05）. Conclusion： The expression level of endostatin is related to the clinical TNM grade, the degree of invasion of the primary tumor and cellular differentiation in the tumor, but not to metastatic spread to lo- cal lymph nodes.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2007年第15期862-864,共3页
Chinese Journal of Clinical Oncology
基金
河北省唐山市科学技术研究与发展指导计划基金资助(编号:06134601a-9)
关键词
贲门腺癌
内皮抑素
临床病理
Cardia gland cancer
Endostatin
Clinical pathology Characterislies
