摘要
抑制素、激活素和卵泡抑素主要由垂体细胞和卵巢颗粒细胞分泌,是细胞转化生长因子-β超家族的成员。通过内分泌及自/旁分泌调节作用参与了女性体内众多的生殖生理活动。本文综述关于抑制素、激活素和卵泡抑素的研究进展,包括生物合成、信号传导的调节、生理作用机制,在女性生殖生理中的重要作用及其相关临床研究及应用。
Activins, inhibins and follistatin are primarily produced in pituitary and ovarian granulosa cell. They are members of the transform growth factor-β （TGF-β） superfamily. They can exert effects on female reproductive processes through endocrine and autocrine-paracrine action. In this review, the structure, physiology, signal transduction pathways and clinical application of the inhibins, activins and follistatin are discussed.
出处
《生殖医学杂志》
CAS
2007年第4期288-292,共5页
Journal of Reproductive Medicine
