摘要
目的：分析我国最低海拔地区吐鲁番维吾尔族成人支气管哮喘的危险因素,为哮喘防治工作提供参考依据.方法：采用1∶1配对设计,选择2005年9月～2006年8在吐鲁番地区医院确诊的门诊及住院的维吾尔族哮喘患者86例（哮喘组）及同期眼科门诊就诊病人86例（对照组）.制定统一的调查表,对所有研究对象进行哮喘危险因素调查及常见血清变应原S-IgE检测,进行单因素分析及多因素的条件Logistic回归分析,并检测中、重度哮喘患者及其对照者血清炎症介质S-ECP、T-IgE水平检测.结果：维吾尔族成人哮喘发作的主要危险因素有呼吸道感染、家族史（一级亲属）、气候变化、过敏史、S-IgE阳性（P＜0.05）.哮喘组中、重度哮喘患者血清S-ECP、T-IgE水平明显高于对照组（P＜0.01）.结论：呼吸道感染、家族史、气候变化、过敏史为维吾尔族成人哮喘发作的主要危险因素;血清S-ECP、T-IgE水平能反映哮喘气道炎症的活动情况.
Objective. To explore the risk of asthma patients among Uyger in Tulufan the lowest altitude region of China, and preventive and therapeutic policies for control of asthma. Methods： Eightysix Uygur asthmatic cases were investigated and 86 controls obtained from ophthalmological outpatient department, and were matched into pair with a ratio of 1 ： 1. Matching was also sought among asthma patients from in terms of age, sex and severity of the disease. Questionnaires were designed to survey the risk factors of bronchial asthma results among all patients, the specific IgE was detected. Data were analyzed with conditional Logistic regression. The serum ECP and total IgE were compared and analyzed. Results.. Bronchial infection, family history, weather change, allergy history, S-IgE positive are major risk factors of bronchial asthma of Uygur in Tulufan region （P 〈0.05）. The levels of S-ECP and T-IgE among moderate to severe asthma patients were significantly higher than control group （P〈0.01）. Conclusion. Respiratory in- fections, family history, weather change, allergic history are the important risk factors of asthma among Uygurs. The levels of S-ECP and T-IgE can become effective means of conducting antiinflammation.
出处
《新疆医科大学学报》
CAS
2007年第7期686-688,共3页
Journal of Xinjiang Medical University
