摘要
目的:对比研究五氟利多暗服药与氟哌啶醇治疗Tourette综合征的疗效和不良反应。方法:68例Tourette综合征患儿随机分为五氟利多组(34例)与氟哌啶醇组(34例),2组均治疗8wk。采用耶鲁抽动程度综合量表(YGTSS)评估治疗效果,采用不良反应症状量表(TESS)评估不良反应。结果:2组间治疗效果无显著性差异(P>0.05);五氟利多组的不良反应较氟哌啶醇组轻,2组间有显著性差异(P<0.01)。结论:五氟利多暗服药与氟哌啶醇治疗Tourette综合征均具有良好效果,但五氟利多暗服药服用方便,不良反应较少。
OBJECTIVE：To evaluate the efficacy and adverse effects of Penfluridol（hidden treatment drug）vs.Haloperidol in the treatment of Tourette syndrome .METHODS： A total of 68 patients with Tourette syndrome were randomly assigned to receive Penfluridol by hidden treatment（n = 34） or Haloperidol（n = 34） for 8wk.The efficacy was evaluated withwith Yale Global Tic Severity Scale（YGTSS） and the adverse effects were evaluated with the Treatment Emergent Symptom Scale （TESS） .RESULTS：There was no significant difference between the two groups in therapeutic efficacy（P 〉 0.05）, however, the side effects in Penfluridol group was less severe than in penfluridol group, showing significant differences between two groups（P〈 0.01） .CONCLUSION： Both Penfluridol and Haloperidol showed satisfactory efficacy for Tourette syndrome, but Penfluridol is convenient to take and it has few ADRs.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第23期1803-1804,共2页
China Pharmacy
