摘要
目的应用13碳-尿素呼气试验(13C-UBT)评估快速尿素酶试验诊断幽门螺杆菌(HP)的价值。方法选择胃镜活检组织快速尿素酶试验HP阴性的胃肠道疾病患者,行13C-UBT检测,并以非胃肠道疾病患者为对照。13C-UBT检查HP阳性病例分三组分别施行质子泵抑制剂(PPI)三联、PPI二联和单纯PPI治疗,治疗后复查13C-UBT,作为评价疗效指标。结果768例快速尿素酶试验HP阴性的患者中,460例13C-UBT结果为HP阳性,阳性率59.9%。对13C-UBT检测HP阳性病例三种治疗后转阴率分别为83.6%,16.4%和3.8%,组间差异显著(P<0.05)。结论对于胃镜胃黏膜组织快速尿素酶试验显示HP阴性的病例,应用13C-UBT有助于提高HP检出率和判断HP根除治疗效果。
Objective To investigate the infection rate of H. pylori through ^13C-urea breath test and the efficacy of H. pylori eradication in patients with H. pylori-negative diagnosed by rapid urease test. Methods ^13C-urea breath test was applied in 768 patients with H. pylori-negative. The patients diagnosed H. pylorbpositive by ^13C-urea breath test received the treatments of PPI-based triple therapy （group A）, proton pump inhibitor （PPI）-based biotherapy （group B） and single-PPI （group C）, respectively. The efficacy of H. pylori eradication was evaluated by ^13C-urea breath test. Results Of 768 patients diagnosed H. pylori-negative by rapid urease test,460 patients showed H. pylori positive by ^13C-urea breath test. The positive rate of H. pylori was 59.9%. The negative rates of ^13C-urea breath test of group A,B and C were 83.6%, 16.4% and 3.8% ,respectively after therapy. Conclusion ^13C-urea breath test can inprove the diagnostic rate of H. pylori in the patients diagnosed H. pylori-negative by rapid urease test.
出处
《江苏医药》
CAS
CSCD
北大核心
2007年第8期794-795,共2页
Jiangsu Medical Journal
