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IL-6和C-反应蛋白与亚临床颈动脉粥样硬化的相关性:Rancho Bernardo研究

Association of Interleukin-6 and C-Reactive Protein With Subclinical Carotid Atherosclerosis(the Rancho Bernardo Study)
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摘要 有关IL-6和C-反应蛋白(CRP)作为动脉粥样硬化预测因素的研究结果混杂。本研究旨在评估IL-6和CRP与12年后检测的亚临床颈动脉粥样硬化严重程度之间的相关性。参与者为来自RanchoBemardo研究的392例成人(56.9%为女性,平均年龄63.2岁),这些参与者在1984-1987年间接受了生化指标检测,在1996-1998年间接受了颈动脉内膜中层厚度(IMT)检测。男性的年龄校正后平均颈动脉IMT显著高于女性的。在校正传统心血管危险因素后,颈动脉IMT随IL-6四分位水平的升高而显著增厚(P〈0.001)。 Studies of interleukin-6(IL-6). and C-reactiVe protein (CRP) as predictors of atherosclerosis have had mixed resuits. The purpose of this study was to assess the associations of IL-6 and CRP with the severity of subclinical carotid atherosclerosis measured 12 years later. Partici- pants were 392 aduhs(56.9% women, mean age 63.2 years) from the Rancho Bernardo Study who had biomarkers measured from 1984 to 1987 and carotid intima-media thickness (IMT) measured from 1996 to 1998. Age-adjusted mean carotid IMT was significantly greater in men than women. After adjusting for traditional cardiovascular risk factors, carotid IMT increased significantly with increasing IL-6 quartiles(p 〈 0. 001 ). In similar analyses, the association between CRP quartiles and carotid IMT was weaker but remained statistically significant(p 〈 0.05).
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