摘要
大气细颗粒物污染与心血管疾病相关，但以往的研究只评估了死亡率和城市之间暴露量的差别。本试验观察了长期暴露于空气动力学粒径小于2．5ixm（PMz5）的颗粒物与心血管事件之间的联系。方法：1994—1998年，纳入美国36个都市地区65893例既往无心血管疾病的绝经后女性，中位随访期为6年。利用距离每例女性住处最近的监测仪评估其暴露于空气污染的水平。校正年龄、民族／种族、吸烟状况、受教育程度、家庭收入、体重指数、有无糖尿病、高血压或高脂血症等因素后，评价其首次心血管事件发生的风险比。
BACKGROUND： Fine particulate air pollution has been linked to cardiovascular disease, but previous studies have assessed only mortality and differences in exposure between cities. We examined the association of long-term exposure to particulate matter of less than 2. 5 μm in aerodynamic diameter（PM25） with cardiovascular events. METHODS： We studied 65, 893 postmenopausal women without previous cardiovascular disease in 36 U.S. metropolitan areas from 1994 to 1998, with a median follow-up of 6 years. We assessed the women＇s exposure to air pollutants using the monitor located nearest to each woman＇s residence. Hazard ratios were estimated for the first cardiovascular event, adjusting for age, race or ethnic group, smoking status, educational level, household income,, body-mass index, and presence or absence of diabetes, hypertension,
