摘要
目的探讨经直肠内线圈三维氢质子磁共振波谱（3D 1H-MRS）诊断前列腺癌的临床价值。方法回顾性分析40例经病理证实的前列腺癌患者资料。采用高分辨MR T2WI和波谱扫描,由2名不知道患者临床和组织学资料的医师对扫描结果进行评价,对比分析前列腺癌MR T2WI和3D1H-MRS的特点。结果前列腺癌区（胆碱＋肌酸）/枸橼酸盐平均值为1．98±1．13,周围正常前列腺组织为0．61±0．16．组间比较差异有统计学意义（P＜0．05）。MR T2WI检出前列腺癌29例,准确率72．5％,3D 1H-MRS检出前列腺癌35例,准确率87．5％,二者比较差异有统计学意义（P＜0．05）。结论3D 1H-MRS诊断前列腺癌准确性高于MR,前列腺癌组织分化程度可影响MRS测定的代谢物浓度或浓度比值。与前列腺癌组织分化程度相对照的大样本研究将有利于MRS中胆碱十肌酸/枸橼酸盐阈值的确定、癌肿恶性程度和外侵趋势的评估。
To evaluate the diagnostic value of endorectal 3D 1H magnetic resonance （MR） spectroscopic imaging on prostate cancer. Methods This was a retrospective study of 40 patients with pathology-- proved prostate cancer. Transverse high-spatial-resolution T2-weighted MR imaging and MR spectroscopic images were analyzed. The MR examinations were evaluated by two radiologists and the MR and 3D 1 H MRS findings were compared. Results The ratio of citrate to creatine plus choline was 1.98± 1. 13 in the regions of cancer and 0. 61 ± 0. 16 in the regions of normal prostate tissue. The difference in ratios between cancer and normal prostate tissue was statistically significant （P〈0.01）. The MR T2WI scan showed a sensitivity of 72.5% （29/40）. 3D 1 H-MRS obtained a sensitivity of 87.5%（35/40）. Conclusions The 3D 1 H-MRS improves the reliability of endorectal MR in the diagnosis and characterization of prostatic cancer. Larger sample study corresponding with histological differentiation of prostatic cancer might help the threshold determination of the creatine＋choline/ citrate, evaluation of tumor grade and the prediction of extracapsular extension.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2007年第8期548-551,共4页
Chinese Journal of Urology
关键词
前列腺肿瘤
癌
磁共振波谱学
Prostatic neoplasms
Carcinoma
Magnetic resonance spectroscopy
