摘要
[目的]建立一种新的系膜增生性肾炎肾小管间质损害模型,并观察肾疏宁的保护作用。[方法]在系膜增生性肾炎(MsPGN)模型基础上,延长造模时间至12～16周,使其自然发展成肾小管间质损害模型,观察肾疏宁对进展性肾小管间质损害的保护作用,并设苯那普利为阳性对照组。[结果]随着造模时间的延长,模型组肾小管间质损害逐渐加重,肾疏宁及苯那普利组损伤程度明显减轻。[结论]系膜增生性肾炎中肾小管间质损害模型成功,中药肾疏宁对肾小管间质损害具有明显的保护作用。
[Objective] To establish a new animal model with progressive tubulointerstitial injury（TII） in rats with Mesenteric proliferative glomerulonephritis and observe the protective effect of Shenshuning（SSN）. [Methods] After inducing of Mesenteric pmhferative glomerulonephritis （MsPGN） the sick rats were allowed survived till 12th -16th weeks and so producing a model tubulointerstitial lesion naturally. With this model the protective effect of the herbal medicine SSN was observed. At the same time, benazepril served as control. [Results] The tubulointerstitial injury was aggravated gradually along with the extension of time in model of rats. SSN and benazepril could distinctly reheve the tubulointerstitial injury. [Conclusions] The model with tubulointerstitial injury has successfully been estalished in rats with mesenteric proliferative glomerulonephritis. The herbal medicine SSN has exhibited distinct protective effect against the tubulointerstitial injury.
出处
《天津中医药》
CAS
2007年第4期325-327,共3页
Tianjin Journal of Traditional Chinese Medicine
基金
自选课题
已通过天津市科委成果鉴定
成果鉴定号为津20070577。
关键词
系膜增生性肾炎
肾小管间质损害
肾疏宁
模型
mesenteric proliferative glomerulonephritis
tubulointerstitial lesions
Shenshuning
Model
